Edible and Medicinal Plants as Nutraceuticals: A Comprehensive Pharmacognostic Review
DOI:
https://doi.org/10.64229/d5fqg290Keywords:
Medicinal plants, Nutraceuticals, Phytochemicals, Pharmacological, PolyphenolsAbstract
Curative and nutritional resources have been discovered in medicine and edible plants. It is an extensive pharmacognostic study of edible, nutraceutical and medicinal plants in relation to its historical aspect, classification, composition of the phytochemicals, pharmacological activity and the research methodology that is currently being carried out. It also discusses the problem of standardization, regulatory problems and safety and makes prospects based on nutraceutical innovation and drug discovery. Considerable phytoconstituents such as polyphenols, flavonoids, terpenoids, alkaloids, and vitamins are studied in light of their nutraceutical worth. Bioactive compounds and their health benefits of some of the plants were discussed which include turmeric (Curcuma longa), garlic (Allium sativum), green tea (Camellia sinensis), ginger (Zingiber officinale), amla (Phyllanthus emblica) and soy (Glycine max). The paper has found out that pharmacognosy has been the focus of discovery, authentication and standardization of the nutraceuticals, linguistic knowledge and modern scientific innovation.
References
[1]Rusciano D, Bagnoli P. The controversial role of nutraceuticals vs. drugs in proliferative retinopathies. Frontiers in Neuroscience, 2025, 19, 1727089. DOI: 10.3389/fnins.2025.1727089
[2]Jain N, Radhakrishnan A, Kuppusamy G. Review on nutraceuticals: Phase transition from preventive to protective care. Journal of Complementary and Integrative Medicine, 2022, 19(3), 553-570. DOI: 10.1515/jcim-2022-0026
[3]Sharma S, Sharma U, Dangi N, Gupta MK, Agrawal A, Mali SN, et al. A comprehensive review on immunoregulatory effects of phytochemicals. Current Drug Discovery Technologies, 2025, 22(3), e15701638326442. DOI: 10.2174/0115701638326442241118053543
[4]Chang X, Zhang T, Zhang W, Zhao Z, Sun J. Natural drugs as a treatment strategy for cardiovascular disease through the regulation of oxidative stress. Oxidative Medicine and Cellular Longevity, 2020, 2020, 5430407. DOI: 10.1155/2020/5430407
[5]Vlaicu PA, Untea AE, Varzaru I, Saracila M, Oancea AG. Designing nutrition for health-incorporating dietary by-products into poultry feeds to create functional foods with insights into health benefits, risks, bioactive compounds, food component functionality and safety regulations. Foods, 2023, 12(21), 4001. DOI: 10.3390/foods12214001
[6]Huang L, Xiao P, Guo L, Gao W. Molecular pharmacognosy. Science China Life Sciences, 2010, 53(6), 643-652. DOI: 10.1007/s11427-010-4006-4
[7]Patwardhan B, Aswar U. Harnessing the potential of ethnopharmacology for future medicines. Journal of Ethnopharmacology, 2025, 353(Pt A), 120359. DOI: 10.1016/j.jep.2025.120359
[8]Nedungadi P, Salethoor SN, Puthiyedath R, Nair VK, Kessler C, Raman R. Ayurveda research: Emerging trends and mapping to sustainable development goals. Journal of Ayurveda and Integrative Medicine, 2023, 14(6), 100809. DOI: 10.1016/j.jaim.2023.100809
[9]Wijewardhana U, Jayasinghe M, Wijesekara I, Ranaweera K. Zingiber officinale, phyllanthus emblica, cinnamomum verum, and curcuma longa to prevent type 2 diabetes: An integrative review. Current Diabetes Reviews, 2023, 19(8), e241122211183. DOI: 10.2174/1573399819666221124104401
[10]Zhao X, Tan X, Shi H, Xia D. Nutrition and traditional chinese medicine (TCM): A system's theoretical perspective. European Journal of Clinical Nutrition, 2021, 75(2), 267-273. DOI: 10.1038/s41430-020-00737-w
[11]Kim IS, Kim CH, Yang WS. Physiologically active molecules and functional properties of soybeans in human health-a current perspective. International Journal of Molecular Sciences, 2021, 22(8), 4054. DOI: 10.3390/ijms22084054
[12]Nasir F, Itrat M, Shahabuddin F, Nikhat S. Effective management of type-2 diabetes mellitus with Unani medications: A case report. Advances in Mind-Body Medicine, 2024, 38(4), 8-13.
[13]López-Rodríguez R, Domínguez L, Fernández-Ruiz V, Cámara M. Extracts rich in nutrients as novel food ingredients to be used in food supplements: A proposal classification. Nutrients, 2022, 14(15), 3194. DOI: 10.3390/nu14153194
[14]Rizvi SAA, Einstein GP, Tulp OL, Sainvil F, Branly R. Introduction to traditional medicine and their role in prevention and treatment of emerging and re-emerging diseases. Biomolecules, 2022, 12(10), 1442. DOI: 10.3390/biom12101442
[15]Johnson R, Fiddler T, Pirozek J, Gordon J, Sodhi S, Poirier J, et al. Traditional medicine and type 2 diabetes in first nations patients. Canadian Journal of Diabetes, 2022, 46(1), 53-59. DOI: 10.1016/j.jcjd.2021.05.007
[16]Sadgrove NJ. Honest nutraceuticals, cosmetics, therapies, and foods (NCTFs): Standardization and safety of natural products. Critical Reviews in Food Science and Nutrition, 2022, 62(16), 4326-4341. DOI: 10.1080/10408398.2021.1874286
[17]Essa MM, Bishir M, Bhat A, Chidambaram SB, Al-Balushi B, Hamdan H, et al. Functional foods and their impact on health. Journal of Food Science and Technology, 2023, 60(3), 820-834. DOI: 10.1007/s13197-021-05193-3
[18]Kulkarni A, Kulkarni CC, Pradeep SR, Poyya J, Kudva AK, Radhakrishnan V, et al. Role of anti-inflammatory and antioxidant properties of natural products in curing cardiovascular diseases. Current Issues in Molecular Biology, 2025, 47(11), 955. DOI: 10.3390/cimb47110955
[19]Hoti G, Matencio A, Rubin Pedrazzo A, Cecone C, Appleton SL, Khazaei Monfared Y, et al. Nutraceutical concepts and dextrin-based delivery systems. International Journal of Molecular Sciences, 2022, 23(8), 4102. DOI: 10.3390/ijms23084102
[20]Liu Y, Wang J, Wu C. Modulation of gut microbiota and immune system by probiotics, pre-biotics, and post-biotics. Frontiers in Nutrition, 2021, 8, 634897. DOI: 10.3389/fnut.2021.634897
[21]Jain DP, Pancholi SS, Patel R. Synergistic antioxidant activity of green tea with some herbs. Journal of Advanced Pharmaceutical Technology & Research, 2011, 2(3), 177-183. DOI: 10.4103/2231-4040.85538
[22]Ballester P, Cerdá B, Arcusa R, Marhuenda J, Yamedjeu K, Zafrilla P. Effect of ginger on inflammatory diseases. Molecules, 2022, 27(21), 7223. DOI: 10.3390/molecules27217223
[23]Skarzynski DJ, Szóstek-Mioduchowska AZ, Rebordão MR, Jalali BM, Piotrowska-Tomala KK, Leciejewska N, et al. Neutrophils, monocytes and other immune components in the equine endometrium: Friends or foes? Theriogenology, 2020, 150, 150-157. DOI: 10.1016/j.theriogenology.2020.01.018
[24]Zhou Y, Xu B. New insights into anti-diabetes effects and molecular mechanisms of dietary saponins. Critical Reviews in Food Science and Nutrition, 2023, 63(33), 12372-12397. DOI: 10.1080/10408398.2022.2101425
[25]Chen Y, Liu Z, Gong Y. Neuron-immunity communication: Mechanism of neuroprotective effects in EGCG. Critical Reviews in Food Science and Nutrition, 2024, 64(25), 9333-9352. DOI: 10.1080/10408398.2023.2212069
[26]Le Bloch J, Rouault M, Iriantsoa V, Michelet O. Polyphenols in human nutrition: European regulations and potential classification as a novel food or food additive. Journal of Agricultural and Food Chemistry, 2024, 72(48), 26936-26942. DOI: 10.1021/acs.jafc.4c08435
[27]Riaz M, Khalid R, Afzal M, Anjum F, Fatima H, Zia S, et al. Phytobioactive compounds as therapeutic agents for human diseases: A review. Food Science & Nutrition, 2023, 11(6), 2500-2529. DOI: 10.1002/fsn3.3308
[28]Kaushik P, Gahalayan A, Parashar S, Rani M, Khurana N, Dogra S, et al. Exploring the multifaceted health benefits of natural dietary sources: Antimicrobial, antioxidant, anticancer, and antidiabetic properties. Recent Patents on Biotechnology, 2025. DOI: 10.2174/0118722083375459250801073140
[29]Ballester P, Cerdá B, Arcusa R, García-Muñoz AM, Marhuenda J, Zafrilla P. Antioxidant activity in extracts from Zingiberaceae family: Cardamom, turmeric, and ginger. Molecules, 2023, 28(10), 4024. DOI: 10.3390/molecules28104024
[30]Osman A, Chittiboyina AG, Avula B, Ali Z, Adams SJ, Khan IA. Quality consistency of herbal products: Chemical evaluation. Progress in the Chemistry of Organic Natural Products, 2023, 122, 163-219. DOI: 10.1007/978-3-031-26768-0_2
[31]Nicolescu A, Babotă M, Barros L, Rocchetti G, Lucini L, Tanase C, et al. Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods. Frontiers in Nutrition, 2023, 10, 1184535. DOI: 10.3389/fnut.2023.1184535
[32]Chen G, Carcea M. Editorial: Advances and trends in nutraceutical and functional plant-based food. Frontiers in Nutrition, 2023, 10, 1168826. DOI: 10.3389/fnut.2023.1168826
[33]Jeyachandran S, Aman M. Valorisation of fish scales and bones: A sustainable source of bioactive proteins and collagen for nutraceuticals. Bioresources and Bioprocessing, 2025, 12(1), 141. DOI: 10.1186/s40643-025-00970-w
[34]El-Seedi HR, Eid N, Abd El-Wahed AA, Rateb ME, Afifi HS, Algethami AF, et al. Honey bee products: Preclinical and clinical studies of their anti-inflammatory and immunomodulatory properties. Frontiers in Nutrition, 2021, 8, 761267. DOI: 10.3389/fnut.2021.761267
[35]Elbandy M. Anti-inflammatory effects of marine bioactive compounds and their potential as functional food ingredients in the prevention and treatment of neuroinflammatory disorders. Molecules, 2022, 28(1), 2. DOI: 10.3390/molecules28010002
[36]Brito R, Costa D, Dias C, Cruz P, Barros P. Chondroitin sulfate supplements for osteoarthritis: A critical review. Cureus, 2023, 15(6), e40192. DOI: 10.7759/cureus.40192
[37]Balthazar CF, Guimarães JF, Coutinho NM, Pimentel TC, Ranadheera CS, Santillo A, et al. The future of functional food: Emerging technologies application on prebiotics, probiotics and postbiotics. Comprehensive Reviews in Food Science and Food Safety, 2022, 21(3), 2560-2586. DOI: 10.1111/1541-4337.12962
[38]Kumari A, K GR, Sudhakaran VA, Warrier AS, Singh NK. Unveiling the health benefits of prebiotics: A comprehensive review. Indian Journal of Microbiology, 2024, 64(2), 376-388. DOI: 10.1007/s12088-024-01235-4
[39]Assan D, Kuebutornye FKA, Hlordzi V, Chen H, Mraz J, Mustapha UF, et al. Effects of probiotics on digestive enzymes of fish (finfish and shellfish); Status and prospects: A mini review. Comparative Biochemistry and Physiology Part B: Biochemistry & Molecular Biology, 2022, 257, 110653. DOI: 10.1016/j.cbpb.2021.110653
[40]Alharbi NA. Polyphenol metabolites in fermented foods: Biotransformation, bioavailability, and functional roles. Frontiers in Nutrition, 2026, 13, 1767453. DOI: 10.3389/fnut.2026.1767453
[41]Elazzazy AM, Baeshen MN, Alasmi KM, Alqurashi SI, Desouky SE, Khattab SMR. Where biology meets engineering: Scaling up microbial nutraceuticals to bridge nutrition, therapeutics, and global impact. Microorganisms, 2025, 13(3), 566. DOI: 10.3390/microorganisms13030566
[42]Liu RH. Health-promoting components of fruits and vegetables in the diet. Advances in Nutrition, 2013, 4(3), 384s-392s. DOI: 10.3945/an.112.003517
[43]Gawish AS, ElMofty MS, Jambi S, Felemban D, Ragheb YS, Elsayed SA. Phytotherapy in periodontics as an effective and sustainable supplemental treatment: A narrative review. Journal of Periodontal & Implant Science, 2024, 54(4), 209-223. DOI: 10.5051/jpis.2301420071
[44]Engwa GA, EnNwekegwa FN, Nkeh-Chungag BN. Free radicals, oxidative stress-related diseases and antioxidant supplementation. Alternative Therapies, Health and Medicine, 2022, 28(1), 114-128.
[45]Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as potential anti-inflammatory molecules: A review. Molecules, 2022, 27(9), 2901. DOI: 10.3390/molecules27092901
[46]Basak S, Gokhale J. Immunity boosting nutraceuticals: Current trends and challenges. Journal of Food Biochemistry, 2022, 46(3), e13902. DOI: 10.1111/jfbc.13902
[47]Cuevas-Cianca SI, Romero-Castillo C, Gálvez-Romero JL, Juárez ZN, Hernández LR. Antioxidant and anti-inflammatory compounds from edible plants with anti-cancer activity and their potential use as drugs. Molecules, 2023, 28(3), 1488. DOI: 10.3390/molecules28031488
[48]Mukhopadhyay N, Shukla A, Makhal PN, Kaki VR. Natural product-driven dual COX-LOX inhibitors: Overview of recent studies on the development of novel anti-inflammatory agents. Heliyon, 2023, 9(3), e14569. DOI: 10.1016/j.heliyon.2023.e14569
[49]Dey R, Dey S, Samadder A, Saxena AK, Nandi S. Natural inhibitors against potential targets of cyclooxygenase, lipoxygenase and leukotrienes. Combinatorial Chemistry & High Throughput Screening, 2022, 25(14), 2341-2357. DOI: 10.2174/1386207325666210917111847
[50]Fik-Jaskółka M, Mittova V, Motsonelidze C, Vakhania M, Vicidomini C, Roviello GN. Antimicrobial metabolites of Caucasian medicinal plants as alternatives to antibiotics. Antibiotics (Basel), 2024, 13(6), 487. DOI: 10.3390/antibiotics13060487
[51]Ayustaningwarno F, Anjani G, Ayu AM, Fogliano V. A critical review of ginger's (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities. Frontiers in Nutrition, 2024, 11, 1364836. DOI: 10.3389/fnut.2024.1364836
[52]Luan R, Ding D, Yang J. The protective effect of natural medicines against excessive inflammation and oxidative stress in acute lung injury by regulating the Nrf2 signaling pathway. Frontiers in Pharmacology, 2022, 13, 1039022. DOI: 10.3389/fphar.2022.1039022
[53]Inchingolo AD, Inchingolo AM, Malcangi G, Avantario P, Azzollini D, Buongiorno S, et al. Effects of resveratrol, curcumin and quercetin supplementation on bone metabolism-a systematic review. Nutrients, 2022, 14(17), 3519. DOI: 10.3390/nu14173519
[54]Medoro A, Davinelli S, Colletti A, Di Micoli V, Grandi E, Fogacci F, et al. Nutraceuticals as modulators of immune function: A review of potential therapeutic effects. Preventive Nutrition and Food Science, 2023, 28(2), 89-107. DOI: 10.3746/pnf.2023.28.2.89
[55]Gasmi A, Shanaida M, Oleshchuk O, Semenova Y, Mujawdiya PK, Ivankiv Y, et al. Natural ingredients to improve immunity. Pharmaceuticals (Basel), 2023, 16(4), 528. DOI: 10.3390/ph16040528
[56]Singh G, Sharma V, Udeh BN. Medicinal plants and lead phytomolecules as immunomodulators: An updated review. BioMed Research International, 2026, 2026, 6998034. DOI: 10.1155/bmri/6998034
[57]Anand S, Bharadvaja N. Potential benefits of nutraceuticals for oxidative stress management. Revista Brasileira de Farmacognosia, 2022, 32(2), 211-220. DOI: 10.1007/s43450-022-00246-w
[58]Siroma TK, Machate DJ, Zorgetto-Pinheiro VA, Figueiredo PS, Marcelino G, Hiane PA, et al. Polyphenols and ω-3 PUFAs: Beneficial outcomes to obesity and its related metabolic diseases. Frontiers in Nutrition, 2021, 8, 781622. DOI: 10.3389/fnut.2021.781622
[59]Djuricic I, Calder PC. Omega-3 (n-3) fatty acid-statin interaction: Evidence for a novel therapeutic strategy for atherosclerotic cardiovascular disease. Nutrients, 2024, 16(7), 962. DOI: 10.3390/nu16070962
[60]Drenjančević I, Pitha J. Omega-3 polyunsaturated fatty acids-vascular and cardiac effects on the cellular and molecular level (narrative review). International Journal of Molecular Sciences, 2022, 23(4), 2104. DOI: 10.3390/ijms23042104
[61]Brosolo G, Da Porto A, Marcante S, Picci A, Capilupi F, Capilupi P, et al. Omega-3 fatty acids in arterial hypertension: Is there any good news? International Journal of Molecular Sciences, 2023, 24(11), 9520. DOI: 10.3390/ijms24119520
[62]Fernandes I, Oliveira J, Pinho A, Carvalho E. The role of nutraceutical containing polyphenols in diabetes prevention. Metabolites, 2022, 12(2), 184. DOI: 10.3390/metabo12020184
[63]Cortez-Navarrete M, Pérez-Rubio KG, Escobedo-Gutiérrez MJ. Role of fenugreek, cinnamon, Curcuma longa, berberine and Momordica charantia in type 2 diabetes mellitus treatment: A review. Pharmaceuticals (Basel), 2023, 16(4), 515. DOI: 10.3390/ph16040515
[64]Nguyen NH, Pham THT, Nguyen NTT, Bui VKH, Van Vo G. Herbal medicine in diabetes treatment: An updated strategy with flavonoid compounds in preclinical and clinical studies. Chemistry & Biodiversity, 2025, 22(10), e02806. DOI: 10.1002/cbdv.202402806
[65]Chauhan S, Singh AP, Rana AC, Kumar S, Kumar R, Singh J, et al. Natural activators of ampk signaling: Potential role in the management of type-2 diabetes. Journal of Diabetes & Metabolic Disorders, 2023, 22(1), 47-59. DOI: 10.1007/s40200-022-01155-4
[66]Singh JK, Chakraborty S, Nagpal M, Aggarwal G. Herbal approach for diabetic cure and futuristic dimension. Current Drug Research Reviews, 2023, 15(3), 207-221. DOI: 10.2174/2589977515666230217114449
[67]Jiao X, Liu X, Cao Q, Deng Z. Plant-based supplements in enhancing exercise performance and recovery. Frontiers in Nutrition, 2025, 12, 1699642. DOI: 10.3389/fnut.2025.1699642
[68]Marino A, Battaglini M, Moles N, Ciofani G. Natural antioxidant compounds as potential pharmaceutical tools against neurodegenerative diseases. ACS Omega, 2022, 7(30), 25974-25990. DOI: 10.1021/acsomega.2c03291
[69]Singh J, Kumar D. In vivo and in vitro perspectives in Parkinson's disease: Mechanisms and the role of phytomedicine. Journal of Food and Drug Analysis, 2025, 33(3), 193-212. DOI: 10.38212/2224-6614.3557
[70]Bhat KMR, Upadhya R, Adiga S, Kumar SEP, Manjula SD, Acharya N, et al. Regulation of chronic neuroinflammation through dietary herbal products. Frontiers in Nutrition, 2025, 12, 1487786. DOI: 10.3389/fnut.2025.1487786
[71]Aggarwal A, Rajalekshmi R, Aggarwal A, Agrawal DK. Plants, pills, and the brain: Exploring phytochemicals and neurological medicines. International Journal of Plant, Animal and Environmental Sciences, 2025, 15(3), 90-114. DOI: 10.26502/ijpaes.4490180
[72]Li RL, Wang LY, Duan HX, Zhang Q, Guo X, Wu C, et al. Regulation of mitochondrial dysfunction induced cell apoptosis is a potential therapeutic strategy for herbal medicine to treat neurodegenerative diseases. Frontiers in Pharmacology, 2022, 13, 937289. DOI: 10.3389/fphar.2022.937289
[73]Qiao J, Wang C, Chen Y, Yu S, Liu Y, Yu S, et al. Herbal/natural compounds resist hallmarks of brain aging: From molecular mechanisms to therapeutic strategies. Antioxidants (Basel), 2023, 12(4), 920. DOI: 10.3390/antiox12040920
[74]Xiang L, Wang Y, Liu S, Liu B, Jin X, Cao X. Targeting protein aggregates with natural products: An optional strategy for neurodegenerative diseases. International Journal of Molecular Sciences, 2023, 24(14), 11275. DOI: 10.3390/ijms241411275
[75]Puri V, Nagpal M, Singh I, Singh M, Dhingra GA, Huanbutta K, et al. A comprehensive review on nutraceuticals: Therapy support and formulation challenges. Nutrients, 2022, 14(21), 4637. DOI: 10.3390/nu14214637
[76]Vrânceanu M, Galimberti D, Banc R, Dragoş O, Cozma-Petruţ A, Hegheş SC, et al. The anticancer potential of plant-derived nutraceuticals via the modulation of gene expression. Plants (Basel), 2022, 11(19), 2524. DOI: 10.3390/plants11192524
[77]Alharbi KS, Almalki WH, Makeen HA, Albratty M, Meraya AM, Nagraik R, et al. Role of medicinal plant-derived nutraceuticals as a potential target for the treatment of breast cancer. Journal of Food Biochemistry, 2022, 46(12), e14387. DOI: 10.1111/jfbc.14387
[78]Trivedi A, Hasan A, Ahmad R, Siddiqui S, Srivastava A, Misra A, et al. Flavonoid myricetin as potent anticancer agent: A possibility towards development of potential anticancer nutraceuticals. Chinese Journal of Integrative Medicine, 2024, 30(1), 75-84. DOI: 10.1007/s11655-023-3701-5
[79]Sailo BL, Liu L, Chauhan S, Girisa S, Hegde M, Liang L, et al. Harnessing sulforaphane potential as a chemosensitizing agent: A comprehensive review. Cancers (Basel), 2024, 16(2), 244. DOI: 10.3390/cancers16020244
[80]Sarma ND, Monagas M, Giancaspro G, Brinckmann JA, Harnly J, Kababick J, et al. Compendial perspectives on botanical identity testing. Journal of Natural Products, 2026, 89(2), 339-351. DOI: 10.1021/acs.jnatprod.5c01200
[81]Shabana, Barkatullah, Nafees M. Pharmacognostic standardization of Xanthium spinosum L. Through scanning electron microscopy and analytical techniques. Microscopy Research and Technique, 2022, 85(12), 3736-3754. DOI: 10.1002/jemt.24224
[82]Öztürk Ş, Ergen Akçin Ö. Microscopic analysis of anatomical and taxonomic characteristics in some centaurea species. Microscopy Research and Technique, 2026, 89(2), 243-259. DOI: 10.1002/jemt.70068
[83]Tian WW, Liu L, Chen P, Yu DM, Li QM, Hua H, et al. Curcuma longa (turmeric): From traditional applications to modern plant medicine research hotspots. Chinese Medical Journal, 2025, 20(1), 76. DOI: 10.1186/s13020-025-01115-z
[84]Elshafie HS, Camele I, Mohamed AA. A comprehensive review on the biological, agricultural and pharmaceutical properties of secondary metabolites based-plant origin. International Journal of Molecular Sciences, 2023, 24(4), 3266. DOI: 10.3390/ijms24043266
[85]Amssayef A, Eddouks M. Alkaloids as vasodilator agents: A review. Current Pharmaceutical Design, 2023, 29(24), 1886-1895. DOI: 10.2174/1381612829666230809094313
[86]Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: A review. Inflammation & Allergy-Drug Targets, 2009, 8(3), 229-235. DOI: 10.2174/187152809788681029
[87]Maugeri A, Lombardo GE, Cirmi S, Süntar I, Barreca D, Laganà G, et al. Pharmacology and toxicology of tannins. Archives of Toxicology 2022, 96(5), 1257-1277. DOI: 10.1007/s00204-022-03250-0
[88]de Sousa DP, Damasceno ROS, Amorati R, Elshabrawy HA, de Castro RD, Bezerra DP, et al. Essential oils: Chemistry and pharmacological activities. Biomolecules, 2023, 13(7), 1144. DOI: 10.3390/biom13071144
[89]Raudone L, Savickiene N. Phytochemical profiles of plant materials: From extracts to added-value ingredients. Plants (Basel), 2024, 13(7), 964. DOI: 10.3390/plants13070964
[90]Lindenmaier MP, Bernart MW, Brinckmann JA. Advanced methodologies for the quality control of herbal supplements and regulatory considerations. Phytochemical Analysis, 2025, 36(8), 2417-2433. DOI: 10.1002/pca.70000
[91]Amir M, Zafar A, Ahmad R, Ahmad W, Sarafroz M, Khalid M, et al. Quality control standardization, contaminant detection and in vitro antioxidant activity of Prunus domestica Linn. Fruit. Plants (Basel), 2022, 11(5), 706. DOI: 10.3390/plants11050706
[92]El-Saadony MT, Saad AM, Mohammed DM, Alkafaas SS, Abd El-Mageed TA, Fahmy MA, et al. Plant bioactive compounds: Extraction, biological activities, immunological, nutritional aspects, food application, and human health benefits-a comprehensive review. Frontiers in Nutrition, 2025, 12, 1659743. DOI: 10.3389/fnut.2025.1659743
[93]Pathaw N, Devi KS, Sapam R, Sanasam J, Monteshori S, Phurailatpam S, et al. A comparative review on the anti-nutritional factors of herbal tea concoctions and their reduction strategies. Frontiers in Nutrition, 2022, 9, 988964. DOI: 10.3389/fnut.2022.988964
[94]Muscolo A, Mariateresa O, Giulio T, Mariateresa R. Oxidative stress: The role of antioxidant phytochemicals in the prevention and treatment of diseases. International Journal of Molecular Sciences, 2024, 25(6), 3264. DOI: 10.3390/ijms25063264
[95]Shanmugam G. Polyphenols: Potent protectors against chronic diseases. Natural Product Research, 2025, 39(23), 6941-6943. DOI: 10.1080/14786419.2024.2386402
[96]Oršolić N, Jazvinšćak Jembrek M. Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer. International Journal of Molecular Sciences, 2022, 23(18), 10479. DOI: 10.3390/ijms231810479
[97]Meccariello R, D'Angelo S. Impact of polyphenolic-food on longevity: An elixir of life. An overview. Antioxidants (Basel), 2021, 10(4), 507. DOI: 10.3390/antiox10040507
[98]Charlton NC, Mastyugin M, Török B, Török M. Structural features of small molecule antioxidants and strategic modifications to improve potential bioactivity. Molecules, 2023, 28(3), 1057. DOI: 10.3390/molecules28031057
[99]Mucha P, Skoczyńska A, Małecka M, Hikisz P, Budzisz E. Overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes. Molecules, 2021, 26(16), 4886. DOI: 10.3390/molecules26164886
[100]Parmenter BH, Dalgaard F, Murray K, Marquis-Gravel G, Cassidy A, Bondonno CP, et al. Intake of dietary flavonoids and incidence of ischemic heart disease in the danish diet, cancer, and health cohort. European Journal of Clinical Nutrition, 2023, 77(2), 270-277. DOI: 10.1038/s41430-022-01226-y
[101]Bellavite P. Neuroprotective potentials of flavonoids: Experimental studies and mechanisms of action. Antioxidants (Basel), 2023, 12(2), 280. DOI: 10.3390/antiox12020280
[102]Kamran S, Sinniah A, Abdulghani MAM, Alshawsh MA. Therapeutic potential of certain terpenoids as anticancer agents: A scoping review. Cancers (Basel), 2022, 14(5), 1100. DOI: 10.3390/cancers14051100
[103]Uvaniskanova Z, Hafez-Ghoran S, Ikhlas Abdjan M, Mountessou BYG, Taktaz F, Mulya F, et al. Anti-inflammatory activity-guided isolation and in silico validation of turmeric (Curcuma longa L.) phytochemicals. Foods, 2025, 14(24), 4205. DOI: 10.3390/foods14244205
[104]Sutopo NC, Qomaladewi NP, Lee HW, Lee MS, Kim JH, Cho JY. Comprehensive understanding and underlying molecular mechanisms of the adaptogenic effects of Panax ginseng. Journal of Ginseng Research, 2025, 49(4), 356-365. DOI: 10.1016/j.jgr.2025.03.013
[105]Zhang Q, Jiang Q, Sa K, Liang J, Sun D, Li H, et al. Research progress of plant-derived natural alkaloids in central nervous system diseases. Phytotherapy Research, 2023, 37(11), 4885-4907. DOI: 10.1002/ptr.7955
[106]Abookleesh FL, Al-Anzi BS, Ullah A. Potential antiviral action of alkaloids. Molecules, 2022, 27(3), 903. DOI: 10.3390/molecules27030903
[107]Vital-Lopez FG, Doty TJ, Reifman J. When to sleep and consume caffeine to boost alertness. Sleep, 2024, 47(10), zsae133. DOI: 10.1093/sleep/zsae133
[108]Musazadeh V, Hamidi N, Noormohammadi M, Shidfar F. The effect of berberis (vulgaris and integerrima) on cardiovascular risk factors in patients with type 2 diabetes mellitus: A systematic review, meta-analysis, and GRADE assessment. Current Therapeutic Research-clinical and Experimental, 2025, 102, 100788. DOI: 10.1016/j.curtheres.2025.100788
[109]Timilsena YP, Phosanam A, Stockmann R. Perspectives on saponins: Food functionality and applications. International Journal of Molecular Sciences, 2023, 24(17), 13538. DOI: 10.3390/ijms241713538
[110]Jiang M, Hong C, Zou W, Ye Z, Lu L, Liu Y, et al. Recent advances in the anti-tumor activities of saponins through cholesterol regulation. Frontiers in Pharmacology, 2024, 15, 1469392. DOI: 10.3389/fphar.2024.1469392
[111]Zarbakhsh S. Effect of antioxidants on preimplantation embryo development in vitro: A review. Zygote, 2021, 29(3), 179-193. DOI: 10.1017/s0967199420000660
[112]Kumari N, Anand S, Shah K, Chauhan NS, Sethiya NK, Singhal M. Emerging role of plant-based bioactive compounds as therapeutics in Parkinson's disease. Molecules, 2023, 28(22), 7588. DOI: 10.3390/molecules28227588
[113]Shahrajabian MH, Sun W. The golden spice for life: Turmeric with the pharmacological benefits of curcuminoids components, including curcumin, bisdemethoxycurcumin, and demethoxycurcumins. Current Organic Synthesis, 2024, 21(5), 665-683. DOI: 10.2174/1570179420666230607124949
[114]Qin T, Chen X, Meng J, Guo Q, Xu S, Hou S, et al. The role of curcumin in the liver-gut system diseases: From mechanisms to clinical therapeutic perspective. Critical Reviews in Food Science and Nutrition, 2024, 64(24), 8822-8851. DOI: 10.1080/10408398.2023.2204349
[115]Abd El-Ghany WA. Potential effects of garlic (Allium sativum L.) on the performance, immunity, gut health, anti-oxidant status, blood parameters, and intestinal microbiota of poultry: An updated comprehensive review. Animals (Basel), 2024, 14(3), 498. DOI: 10.3390/ani14030498
[116]Dai X, Azi F, Alnadari F, Yu Z. Developing organosulfur compounds in Allium as the next-generation flavor and bioactive ingredients for food and medicine. Critical Reviews in Food Science and Nutrition, 2025, 65(33), 8406-8424. DOI: 10.1080/10408398.2025.2500674
[117]Farhan M. Green tea catechins: Nature's way of preventing and treating cancer. International Journal of Molecular Sciences, 2022, 23(18), 10713. DOI: 10.3390/ijms231810713
[118]Samanta S. Potential bioactive components and health promotional benefits of tea (Camellia sinensis). Journal of the American Nutrition Association, 2022, 41(1), 65-93. DOI: 10.1080/07315724.2020.1827082
[119]Pathak S, Pratap A, Sharma R, Jha MK. The Phyllanthus emblica fruits: A review on phytochemistry traditional uses, bioactive composition and pharmacological activities. Current Topics in Medicinal Chemistry, 2024, 24(22), 1917-1939. DOI: 10.2174/0115680266321320240708060327
[120]Intharuksa A, Arunotayanun W, Na Takuathung M, Chaichit S, Prasansuklab A, Chaikhong K, et al. Daidzein and genistein: Natural phytoestrogens with potential applications in hormone replacement therapy. International Journal of Molecular Sciences, 2025, 26(14), 6973. DOI: 10.3390/ijms26146973
[121]Vittal M, Vinciguerra M. Enhancing healthspan with ashwagandha (Withania somnifera): A comprehensive review of its multifaceted geroprotective benefits. Biogerontology, 2025, 26(5), 179. DOI: 10.1007/s10522-025-10320-0
[122]Arya R, Faruquee HM, Shakya H, Rahman SA, Begum MM, Biswas SK, et al. Harnessing the antibacterial, anti-diabetic and anti-carcinogenic properties of Ocimum sanctum Linn (Tulsi). Plants (Basel), 2024, 13(24), 3516. DOI: 10.3390/plants13243516
[123]Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, et al. Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging. Archives of Toxicology, 2023, 97(10), 2499-2574. DOI: 10.1007/s00204-023-03562-9
[124]Chaudhary P, Janmeda P, Docea AO, Yeskaliyeva B, Abdull Razis AF, Modu B, et al. Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 2023, 11, 1158198. DOI: 10.3389/fchem.2023.1158198
[125]Bagherniya M, Mahdavi A, Abbasi E, Iranshahy M, Sathyapalan T, Sahebkar A. The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: A clinical review. Inflammopharmacology, 2022, 30(1), 91-110. DOI: 10.1007/s10787-021-00902-y
[126]Giurranna E, Nencini F, Bettiol A, Borghi S, Argento FR, Emmi G, et al. Dietary antioxidants and natural compounds in preventing thrombosis and cardiovascular disease. International Journal of Molecular Sciences, 2024, 25(21), 11457. DOI: 10.3390/ijms252111457
[127]Kashtoh H, Baek KH. New insights into the latest advancement in α-amylase inhibitors of plant origin with anti-diabetic effects. Plants (Basel), 2023, 12(16), 2944. DOI: 10.3390/plants12162944
[128]Grabska-Kobyłecka I, Szpakowski P, Król A, Książek-Winiarek D, Kobyłecki A, Głąbiński A, et al. Polyphenols and their impact on the prevention of neurodegenerative diseases and development. Nutrients, 2023, 15(15), 3454. DOI: 10.3390/nu15153454
[129]Ahmed M. Targeting aging pathways with natural compounds: A review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol. Immunity & Ageing, 2025, 22(1), 28. DOI: 10.1186/s12979-025-00522-y
[130]Shimizu M, Weinstein IB. Modulation of signal transduction by tea catechins and related phytochemicals. Mutation Research, 2005, 591(1-2), 147-160. DOI: 10.1016/j.mrfmmm.2005.04.010
[131]Petrovic SM, Barbinta-Patrascu ME. Organic and biogenic nanocarriers as bio-friendly systems for bioactive compounds' delivery: State-of-the art and challenges. Materials (Basel), 2023, 16(24), 7550. DOI: 10.3390/ma16247550
[132]Chavda VP, Patel AB, Mistry KJ, Suthar SF, Wu ZX, Chen ZS, et al. Nano-drug delivery systems entrapping natural bioactive compounds for cancer: Recent progress and future challenges. Frontiers in Oncology, 2022, 12, 867655. DOI: 10.3389/fonc.2022.867655
[133]Dwivedi K, Sahoo A, Almalki WH, Almujri SS, Aodah A, Alruwaili NK, et al. Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy. Nanomedicine (Lond), 2025, 20(1), 91-116. DOI: 10.1080/17435889.2024.2440301
[134]Hlatshwayo S, Thembane N, Krishna SBN, Gqaleni N, Ngcobo M. Extraction and processing of bioactive phytoconstituents from widely used South African medicinal plants for the preparation of effective traditional herbal medicine products: A narrative review. Plants (Basel), 2025, 14(2), 206. DOI: 10.3390/plants14020206
[135]Herzyk F, Piłakowska-Pietras D, Korzeniowska M. Supercritical extraction techniques for obtaining biologically active substances from a variety of plant byproducts. Foods, 2024, 13(11), 1713. DOI: 10.3390/foods13111713
[136]Evans M, Lewis ED, Antony JM, Crowley DC, Guthrie N, Blumberg JB. Breaking new frontiers: Assessment and re-evaluation of clinical trial design for nutraceuticals. Frontiers in Nutrition, 2022, 9, 958753. DOI: 10.3389/fnut.2022.958753
[137]Vashishat A, Patel P, Das Gupta G, Das Kurmi B. Alternatives of animal models for biomedical research: A comprehensive review of modern approaches. Stem Cell Reviews and Reports, 2024, 20(4), 881-899. DOI: 10.1007/s12015-024-10701-x
[138]Aleta A, Brighenti F, Jolliet O, Meijaard E, Shamir R, Moreno Y, et al. A need for a paradigm shift in healthy nutrition research. Frontiers in Nutrition, 2022, 9, 881465. DOI: 10.3389/fnut.2022.881465
[139]Gaur A, Singhal N, Vardhan H, Jain R, Bist Y, Wagri NK. Cultivation to consumption: Strengthening bacterial safety in plant-based nutraceuticals. Frontiers in Microbiology, 2025, 16, 1698580. DOI: 10.3389/fmicb.2025.1698580
[140]Afzal I, Haq MZU, Ahmed S, Hirich A, Bazile D. Challenges and perspectives for integrating quinoa into the Agri-food system. Plants (Basel), 2023, 12(19), 3361. DOI: 10.3390/plants12193361
[141]Noviana E, Indrayanto G, Rohman A. Advances in fingerprint analysis for standardization and quality control of herbal medicines. Frontiers in Pharmacology, 2022, 13, 853023. DOI: 10.3389/fphar.2022.853023
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