Development and Clinical Assessment of Oral Dispersible Tablet of Cordia Dicotoma and Salvia Hispanica Mucilage for the Management of Stomatitis
DOI:
https://doi.org/10.63623/j1x9p609Keywords:
Cordia dicotoma, Salvia hispanica, Ascorbic acid, StomatitisAbstract
The main objective was to formulate and clinical assessment of oral dispersible tablet comprising mucilage of Cordia dicotoma and Salvia hispaica in the management of stomatitis. The mucilage formed from macerating Cordia dicotoma fruits with solvent water and 1% HCl, Salvia hispaica were extracted using a 1:40 water ratio, stirred for two hours, then centrifuged to extract the mucilage. Pre-formulation and post-compressional studies were conducted for all the oral dispersible tablet formulations. A clinical study was conducted using the optimized formulation and evaluated for the clinical parameters such as red patch, blisters, swelling, pain and burning sensation for 14 days and grading of improvement for stomatitis was given by the subjects before and after treatment. When oral dispersible tablets were made with different amounts of mucilage, they dissolved quickly and took less time to release ascorbic acid hence tablet containing 150 mg of Cordia dicotoma, 100 mg of Salvia hispaica and 20 mg of red rock sugar was selected for a clinical investigation. Clinical parameters indicated the improvement of 68.54% for red patch, 70.07% for blisters, 68.86% for swelling, 67.49% for pain and 68.27% for burning sensation. Based on above clinical parameters developed formulation can be used for the management of stomatitis.
References
[1]Gallo CD, Mimura MA, Sugaya NN. Psychological stress and recurrent aphthous stomatitis. Clinics (Sao Paulo), 2009, 64(7), 645-648. DOI: 10.1590/S1807-59322009000700007
[2]Nayak AK, Manna K. Current developments in orally disintegrating tablet technology. Journal of Pharmaceutical Education and Research, 2011, 2(1), 21.
[3]Prajapati SK, Kar M, Maurya SD, Pandey R, Dhakar RC. Exploring phytochemicals and pharmacological uses of Cordia Dichotoma (Indian cherry): a review. Journal of Drug Delivery and Therapeutics, 2017, 7(6), 125-131. DOI: 10.22270/jddt.v7i6.1438
[4]Jamkhande PG, Barde SR, Patwekar SL, Tidke PS. Plant profile, phytochemistry and pharmacology of Cordia Dichotoma (Indian cherry): a review. Asian Pacific Journal of Tropical Biomedicine, 2013, 3(12), 1009-1012. DOI: 10.1016/S2221-1691(13)60194-X
[5]Knez Hrnčič M, Ivanovski M, Cör D, Knez Ž. Chia Seeds (Salvia hispanica L.): an overview__phytochemical profile, isolation methods, and application. Molecules, 2019, 25(1), 11. DOI: 10.3390/molecules25010011
[6]Xu K, Zhou C, Huang F, Duan N, Wang Y, et al. Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study. Journal of International Medical Research, 2021, 49(5), 03000605211017724. DOI: 10.1177/03000605211017724
[7]Pawar HA, Gavasane AJ, Choudhary PD. Extraction of polysaccharide from fruits of Cordia dichotoma G. Forst using acid precipitation method and its physicochemical characterization. International Journal of Biological Macromolecules, 2018, 115, 871-875. DOI: 10.1016/j.ijbiomac.2018.04.146
[8]Punia S, Dhull SB. Chia seed (Salvia hispanica L.) mucilage (a heteropolysaccharide): functional, thermal, rheological behaviour and its utilization. Journal of Biological Macromolecules, 2019, 140, 1084-1090. DOI: 10.1016/j.ijbiomac.2019.08.205
[9]Kulkarni GT, Gowthamarajan K, Rao BG, Suresh B. Evaluation of binding properties of Plantago Ovata and Trigonella Foenum Graecum mucilages. Indian Drugs, 2002, 39(8), 422-425.
[10]Desai AP, Desai S. UV spectroscopic method for determination of vitamin C (ascorbic acid) content in different fruits in south Gujarat Region. International Journal of Environmental Sciences & Natural Resources, 2019, 21(2), 41-44. DOI: 10.19080/IJESNR.2019.21.556056
[11]Pancham YP, Girish B, Sanjay SS. UV-spectrophotometric method for quantification of ascorbic acid in bulk powder. The Pharma Innovation Journal, 2020, 9(5), 05-08.
[12]Swain RP, Nagamani R, Panda S. Formulation, in vitro characterization and stability studies of fast dispersing tablets of diclofenac sodium. Journal of Applied Pharmaceutical Science, 2015, 5(7), 094-102. DOI: 10.7324/JAPS.2015.50715
[13]Kumarı A, Kumar R, Singh B. Formulation and evaluation of delayed release capsule of dimethyl fumarate with novel technology. International Journal of Pharmaceutical Research, 2019, 11(4), 745-753. DOI: 10.31838/ijpr/2019.11.04.073
[14]Shah B, Kotadiya M, Sheth Z, Bhatt RJ. Formulation and characterization of oral dispersible tablet of aprepitant. Research Journal of Pharmacy and Technology, 2023, 16(5), 2375-2380. DOI: 10.52711/0974-360X.2023.00391
[15]Mayuri K, Kumar KP, Swapna N, Mohan CK. Formulation and evaluation of triclosan dispersible tablets for oral hygiene. Research Journal of Pharmacy and Technology, 2021, 14(6), 3202-3208. DOI: 10.52711/0974-360X.2021.00558
[16]Naik SB, Venkateswarlu K, Chandrasekhar KB. Formulation and in-vitro evaluation of orodispersible tablets of olanzapine for the improvement of dissolution rate. Journal of Chemical and Pharmaceutical Research, 2016, 8(1), 177-181. DOI: 10.4103%2F0250-474X.98984
[17]Samanthula K, Gna L, Reddy J, Hoque N, Sen S, et al. Design, development and influence of super disintegrants on solid dispersion based taste masking orodispersible tablets of racecadotril. European Chemical Bulletin, 2023, 12, 12474-12500. DOI: 10.48047/ecb/2023.12.10.880
[18]Roy D, De A, Biswas S, Pramanick N, Das A, et al. An overview on mouth dissolving tablets. Journal of Huazhong University of Science and Technology, 2022, 1671, 4512.
[19]European Pharmacopeia. UK. Ph Eur monograph, 2010.
[20]Jakki R, Afzal Syed M, Kandadi P, Veerabrahma K. Development of a self-microemulsifying drug delivery system of domperidone: In vitro and in vivo characterization. Acta Pharmaceutica, 2013, 63, 241-251. DOI: 10.2478/acph-2013-0013
[21]Sheth PR, Tossounian JL. Sustained release tablet formulations. US Patent. 1979, 4(140), 755.
[22]Bhardwaj S, Jain V, Jat RC, Mangal A, Jain S. Formulation and evaluation of fast dissolving tablet of aceclofenac. International Journal of Drug Delivery, 2010, 2(1), 93-97. DOI: 10.5138/ijdd.2010.0975.0215.02017
[23]Chaturvedi H, Garg A, Rathore US. Post-compression evaluation parameters for tablets-an overview. European Journal Pharmaceutical and Medical Research, 2017, 4(11), 526-530.
[24]Singh J, Singh R. Optimization and Formulation of Orodispersible Tablets of Meloxicam. Tropical Journal of Pharmaceutical Research, 2009, 8(2), 153-159. DOI: 10.4314/tjpr.v8i2.44524
[25]Kamboj M, Goyal S, Rakha P, Arora G, Dureja H, et al. Formulation and evaluation of metformin oro-dispersible tablets. Acta Poloniae Pharmaceutica-Drug Research, 2011, 68(5), 717-723.
[26]Al-Oudah GA, AmeerHamdi AL, Shwailiya SA, AL-Ameedee AH. Activity of zinc oral dispersible tablet on marjory clinical type of recurrent aphthous stomatitis ulceration, a clinical trial human study. EC Dental Science, 2019, 18, 1580-1586. DOI: 10.36295/ASRO.2020.231201
[27]Salehi M, Saeedi M, Ehsani H, Sharifian A, Moosazadeh M, et al. Analyzing Glycyrrhiza Glabra (licorice) extract efficacy in recurrent aphthous stomatitis recovery. Journal of Research in Medical and Dental Science, 2018, 6(1), 68-75. DOI: 10.24896/jrmds.20186112
[28]Madaan R, Bala R, Zandu SK, Singh I. Formulation and characterization of fast dissolving tablets using Salvia Hispanica (chia seed) mucilage as superdisintegrant. ACTA Pharmaceutica Sciencia, 2020, 58(1), 69-82. DOI: 10.23893/1307-2080.APS.05805
[29]Shah D, Prasad N, Limbani B. Gasroprotective and antiulcer effect of Cordia Dichotoma. International Journal of Pharmaceutics, 2011, 2(9), 70-72.
[30]Pintapagung T, Asawapattanakul T. Effect of chia (Salvia hispanica L.) seed extract on wound healing in mice. Veterinary Integrative Sciences, 2020, 18(2), 103-117.
[31]Scardina GA, Messina P. Good oral health and diet. Journal of Biomedicine and Biotechnology, 2012, (1), 720692. DOI: 10.1155/2012/720692
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